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KMID : 0861020000150010001
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Korea Journal of Herbology
2000 Volume.15 No. 1 p.1 ~ p.17
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The Experimental Studies on the Reinforcemental Effects of Acanthopanax Radicis Cortex about Immunity Hematogenic Action
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任中根/Lim, Joong-Keun
徐榮培/金東熙/薛仁燦/Seo, Young-Bae/Kim, Dong-Hee/Seol, In-Chan
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Abstract
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In order to investigate the reinforcemental Effects of Acanthopanax Radicis Cortex about immunity and hematogenic action. The various immune responses were studied.
The results were obtained as follows:
1. Positive cell was significantly increased at the 0.25 d r n P degree of density in the effect of CD4 about the spleen cell.
2. In the effect of IgG positive cell was significantly increased as comrared with the data of control only at the 0.25 mg/ml degree of density.
3. In the effect of Mac-1 positive cell was significantly increased in all treated degree of density.
4. In result of observing the change of WBC after Cyclophosphamide-processing the number of WBC was significantly increased in treated Group.
5. Measurement of RT-PCR in Hematopoietic stem cell TPO PCR products was increased as compared with medium at the 1 ㎛/ml degree of density.
6. In reinforcemental effect about Stem cell factor SCF PCR product was increased as compared with medium at the low degree of density.
7. In reinforcemental effect about IL-3 PCR product was increased as compared with medium at the low degree of density.
8. In reinforcemental effect about IL-6 PCR product was significantly increased as compared with all treated group.
9. Assay about positive cell in the spleen cell, the positive cell was significantly increased in CD4, CD19.
10. Created amount NO was treated group significantly increased all degree of density.
11. In promotional dissolution-effect, treated group was increased one and half times or twice all degree of density as compared with negative control.
According to the above results, Acanthopanax Radicis Cortex increase coherence with T-cell by dint of activating CD of T-cell, presentate an antigen, activate IL-3, IL-6 which stimulate B-cell mading an antibody, activate IFN- y which appeal anti-viral activity by dint of activating macrophage, activate IgG which being made in B-cell neutralize Virus directly, increase immunity by means of promoting dissolution of Spleen cell which involve immune cell and strengthen hematogenic action by dint of activating TPO, SCF.
Although Acanthopanax Radicis Cortex was used in retrogressional joint disease of deficiency syndrome by reinforcing Liver and Kidney, strengthening bones and sinews, because IFN- 7 which appeal anti-viral activity and IL-6 which almost appear in arthritis increased significantly, in future we should make an effort in looking into action of Acanthopanax Radicis Cortex about common cold by infection and arthritis of excess syndrome.
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